Experimental Evaluation of antidiabetic activity of Swertia Chirata – Aqueous Extract

Aims : The present study evaluates the antidiabetic activity of Swertia chirata (aqueous extract) on the blood glucose level of streptozotocin induced diabetic rat models. Objectives : i) To study the antidiabetic activity of aqueous extract of Swertia chirata in streptozotocin induced diabetes in albino rats. ii) To compare the antidiabetic activity of Swertia chirata extracts with that of standard drug glibenclamide used in the treatment of type 2 diabetes mellitus. Materials and Methods: In the present study 24 male albino wistar rats divided into 4 groups with 6 animals were taken. One group as control was given normal saline for 21 days daily. Other 3 groups were induced diabetes. Standard and test groups were fed with glibenclamide (0.5mg/kg) and aqueous extract (200mg/kg) daily for 21 days respectively. Result : The results were analysed with ANOVA (Analysis of Variance) and comparison with standard, test and control groups done by post hoc tukeys test. p<0.001 was considered highly significant.